ISSN 1662-4009 (online)

ey0017.9-5 | Fertility-Related Issues | ESPEYB17

9.5. Leydig cell function in male survivors of childhood cancer: A report from the St Jude lifetime cohort study

W Chemaitilly , Q Liu , L van Iersel

To read the full abstract: J Clin Oncol. 2019;37(32):3018–3031. wassim.chemaitilly@stjude.orgThis retrospective study, with cross-sectional health outcomes analysis, evaluated Leydig cell function in 1516 childhood cancer survivors at a median duration of 22.0 years after cancer diagnosis. These patients are part of the St Jude Lifetime Cohort. An age- and sex-matched community control grou...

ey0016.11-14 | Treatment of Severe Obesity: Next Steps | ESPEYB16

11.14. Pathophysiology and individualized treatment of hypothalamic obesity following craniopharyngioma and other suprasellar tumors: a systematic review

L van Iersel , KE Brokke , RAH Adan , LCM Bulthuis , ELT van den Akker , HM van Santen

To read the full abstract: Endocr Rev. 2019;40(1):193–235This paper combines a comprehensive review of current knowledge on pathophysiologic mechanisms contributing to hypothalamic obesity in craniopharyngioma patients with a systematic literature review of intervention studies for weight management in this patient population. Findings of both reviews are merged into evidence-...

ey0020.7-14 | Long-Term Surveillance for Endocrine Complications in Childhood Cancer Survivors | ESPEYB20

7.14. Hypothalamic-pituitary and other endocrine surveillance among childhood cancer survivors

L van Iersel , RL Mulder , C Denzer , LE Cohen , HA Spoudeas , LR Meacham , E Sugden , AYN Schouten-van Meeteren , EW Hoving , RJ Packer , GT Armstrong , S Mostoufi-Moab , AM Stades , D van Vuurden , GO Janssens , C Thomas-Teinturier , RD Murray , N Di Iorgi , SJCMM Neggers , J Thompson , AA Toogood , H Gleeson , C Follin , E Bardi , L Torno , B Patterson , V Morsellino , G Sommer , SC Clement , D Srivastava , CE Kiserud , A Fernandez , K Scheinemann , S Raman , KCJ Yuen , WH Wallace , LS Constine , R Skinner , MM Hudson , LCM Kremer , W Chemaitilly , HM van Santen

Brief summary: In this extensive and updated review, the International Late Effects of Childhood Cancer Guideline Harmonization Group (IGHG) report expert consensus-based guidelines that harmonize recommendations for surveillance of endocrine disorders in childhood cancer survivors.This interdisciplinary panel of 42 international experts formulated new surveillance recommendations for hypothalamic–pituitary (HP) dysfunction. Existing IGHG surveillan...